The upper airway parameter: the potential prognostic clue for congenital diaphragmatic hernia-a prospective randomized controlled study.

ABSTRACT:

Purpose

In our previous studies, differences in the upper airway inner diameter between fetuses with thoracic space occupying lesions and normal fetuses were found, but their clinical value has not been further validated. We designed a prospective case-control animal experiment to validate its prognostic value in congenital diaphragmatic hernia (CDH).

Methods

Using Nitrofen to create a fetal SD-rat model of CDH. Calculate the upper airway inner diameter and lung parameters of fetal rats on ultrasonic image and histology sections, and calculate the correlation between the upper airway and lung parameters. Design experiments to rule out the impact of major cardiac malformations on airway development, the correlation between the upper airway inner diameter and the area of CDH w

SUBMITTER: Song S 

PROVIDER: S-EPMC12799750 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature