Contour-informed inter-patient deformable registration for more reliable voxel-based analysis of Head-and-Neck cancer patients.

ABSTRACT:

Background and purpose

The registration of individual dose distributions to a reference anatomy represents a key step in voxel-based analysis (VBA), a tool for spatially informed dose-response assessment. Accurate deformable image registration (DIR) is essential for addressing anatomical variability across patients. To improve both global and region-specific alignment, we enhanced our in-house DIR algorithm (CPT-DIR) by incorporating contour-informed regularization.

Materials and methods

We evaluated contour-informed CPT-DIR using CT images from 37 Head-and-Neck patients, with seven cases providing ground-truth dose distribution for dose warping validation. Organs at risk (OARs) were delineated manually, with bone contours auto-generated using TotalSegmentator. Contour-infor

SUBMITTER: Ruan X 

PROVIDER: S-EPMC12799766 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature