Healthcare professionals' experiences returning monogenic, polygenic, and integrated risk results in the eMERGE study.

ABSTRACT: Clinical interest in polygenic (PRS) and integrated (PRS plus clinical factors) risk scores (IRS) is growing, yet little data exist on how healthcare providers navigate returning these results to patients. The eMERGE IV study implemented a genome-informed risk assessment for 11 common complex conditions, incorporating PRS, IRS, and monogenic findings, offering an opportunity to examine providers' experiences disclosing these results. We used a cross-sectional survey with closed- and open-ended questions to assess result disclosure experiences. All study providers involved in disclosing high-risk results were invited to participate. Of 21 respondents, 86% were female and the mean age was 35 years. Most were genetic counselors (76%), followed by pharmacists (10%), research coordinators (10%)

SUBMITTER: Suckiel SA 

PROVIDER: S-EPMC12799777 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature