Viewing direct-to-consumer genetic test results for depression risk is psychologically well tolerated: Evidence from a longitudinal equivalence study.

ABSTRACT: Depression is a frequent focus of interest in genetic testing. Despite the growing availability of polygenic risk scores (PRSs) for depression, little is known about the psychological impact of receiving them in real-world settings. To quantify the impact of receiving an at-risk depression PRS result on depression and anxiety symptoms, we conducted a longitudinal, prospective cohort study of 23andMe research participants. Eligible participants were US residents 18 years old and older who completed two surveys between October 19, 2022 and October 9, 2023 assessing depression and anxiety symptoms and who had an at-risk PRS for depression (odds ratio ≥1.5). We compared 361 individuals who viewed their result with 556 who did not. Primary outcomes were changes in depression (Patient Health Que

SUBMITTER: Berns RMK 

PROVIDER: S-EPMC12799781 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature