Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD.

ABSTRACT:

Background

Disruptions in early-life gut microbiota and metabolites associated with maternal Western-style diet (WD) during critical windows of development are linked to metabolic and inflammatory diseases in offspring, including metabolic dysfunction-associated steatotic liver disease (MASLD) in later life. These disturbances can alter microbial metabolite production, such as tryptophan derivatives, which are crucial for immune and metabolic regulation. However, the specific effects of maternal supplementation with tryptophan metabolites on offspring gut microbiome maturation and MASLD risk remain unexplored.

Methods

WD-fed mouse dams were supplemented with microbial metabolites indole (Ind) or indole-3-acetic acid (I3A) during gestation and lactation; male offspring were w

SUBMITTER: Mandala A 

PROVIDER: S-EPMC12799784 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature