TMT1A inhibits lung adenocarcinoma progression by suppressing M2 macrophage polarization.

ABSTRACT: The role of thiol methyltransferase 1A (TMT1A) in lung adenocarcinoma (LUAD) progression and the immune microenvironment remains unclear. Analysis of clinical samples and public databases revealed significantly lower TMT1A expression in tumorous LUAD samples compared to non-neoplastic counterparts. Cox regression analysis confirmed TMT1A as an independent prognostic factor for LUAD. Phenotypically, functional assays demonstrated that TMT1A expression inhibited LUAD cell proliferation and migration. Furthermore, single cell transcriptome sequencing analysis showed that TMT1A expression was positively correlated with the immune cells, especially macrophages. Mechanistically, high TMT1A expression was found to inhibit M2 macrophage polarization and downregulate PD-L1 expression

SUBMITTER: Pan J 

PROVIDER: S-EPMC12799785 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature