Talin1 modulates the Piezo1-YAP axis to regulate endothelial cell inflammation and atherosclerosis.

ABSTRACT:

Background

Atherosclerosis is a chronic vascular inflammatory disease caused by multiple factors. Anti-inflammatory treatment is an effective approach to treat atherosclerosis. Talin1 is a cell membrane-associated cytoskeletal protein that is widely expressed in mammals and plays essential roles in angiogenesis and endothelial cell barrier function. However, the role of Talin1 in atherosclerosis and the related mechanisms remains unclear.

Methods

ApoE-KO mice were subjected to partial carotid artery ligation to establish an atherosclerosis model, and the expression of Talin1 in atherosclerotic plaques was verified in vivo. Human umbilical vein endothelial cells (HUVECs) and aortic endothelial cells (HAECs) were treated with tumour necrosis factor α (TNF-α) (10 ng/mL) and sub

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12799834 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature