Xenograft tissue slice tandem co-cultures are a highly specific model to selectively analyze drug inhibitory effects on glioblastoma invasion.

ABSTRACT: Test systems enabling preclinical assessment of drug effects in relevant models are essential for optimizing the selection of candidate therapeutics before their further clinical translation. Xenograft tissue slice tandem co-culture (XTCC) models were developed as ex vivo systems for visualizing glioblastoma (GBM) tumor growth and invasion into the complex host tissue structures of the brain. Work here tested the XTCC model for delineating specific drug effects, in particular inhibition of invasion as major issue in GBM. The established chemotherapeutic Temozolomide (TMZ) and three promising candidates - two histone deacetylase inhibitors, Vorinostat and Entinostat, and the neuropeptide Apamin - were tested. XTCCs were generated by placing G55T2 or U87-MG cell-derived tumor xenograft tissu

SUBMITTER: Wagner KK 

PROVIDER: S-EPMC12799928 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature