Association of treatment decision with personality, coping strategies and impulsivity in patients with multiple sclerosis.

ABSTRACT:

Introduction

Shared decision-making is advocated in treating patients with multiple sclerosis (pwMS), enabled by the wide range of disease-modifying treatments (DMTs). However, the role of psychological characteristics in treatment decisions remains understudied.

Methods

In a prospective study, pwMS completed the Big Five Trait inventory, UPPS Impulsive Behaviour Scale and Brief COPE at treatment initiation. Associations between choosing high-efficacy DMTs (H-DMT; natalizumab, anti-CD20 monoclonal antibodies) versus low/moderate-efficacy DMTs were analysed using logistic regression, for each dimension separately, then in a multidimensional model. Propensity scoring adjusted for MS-associated determinants of DMT choice (sex, age, disease duration, prior DMT, relapse in previo

SUBMITTER: Nolte JP 

PROVIDER: S-EPMC12799969 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature