Effect of Lower Limb Alignment and Corrective Osteotomy on Clinical Outcomes After Matrix-Associated Autologous Chondrocyte Implantation for Extensive Cartilage Defects of the Knee.

ABSTRACT:

Background

The effectiveness of matrix-associated autologous chondrocyte implantation (MACI) in patients with lower limb malalignment remains debatable.

Hypothesis

Performing MACI in patients with lower limb alignment abnormalities would result in worse postoperative outcomes than in those without alignment abnormalities.

Study design

Cohort study; Level of evidence, 3.

Methods

Patients who underwent MACI using autologous cultured cartilage for traumatic chondral defects and osteochondritis dissecans across 3 institutions between February 2014 and August 2022 were reviewed. Osteotomy was recommended for patients with mechanical alignment (MA) <40% and performed on consenting patients. Evaluation included demographic and clinical variables, Lysholm Knee Score (L

SUBMITTER: Maeyama A 

PROVIDER: S-EPMC12799972 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature