Integrated Network Analysis Reveals a Directly Regulatory Network of FOXM1 Associated With the Cell Cycle in Lung Adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) has emerged as both the most frequently diagnosed malignancy and the predominant contributor to cancer-related mortality worldwide. Current clinical evidence indicates that a significant proportion of LUAD cases exhibit tumor cells characterized by accelerated proliferative activity, which contributes to the aggressive biological behavior. Six microarray data sets were retrieved from the Gene Expression Omnibus (GEO), and differentially expressed genes (DEGs) were identified using the robust rank aggregation (RRA) method. The mRNA and protein levels of selected genes were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and western blot (WB). Short interfering RNA (siRNA)-mediated knockdown combined with E

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12799991 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature