Platelets in angiogenesis and pulmonary progenitor cell homing under chronic intermittent hypoxia.

ABSTRACT: Platelets play a critical role in tissue repair and contain various molecules that regulate angiogenesis, such as stromal cell-derived factor-1 (SDF-1) which stimulates endothelial progenitor cells (EPCs). Chronic intermittent hypoxia (CIH) alters platelet function, but its specific impact on platelet-derived angiogenic factors and endothelial progenitor cell (EPC) recruitment in lung injury remains unclear. This study investigated the effects of CIH on the profile of pro- and anti-angiogenic molecules in platelets and their role in EPC homing during acute lung injury (ALI). Ten-week-old 35 rats were divided into control, ALI, CIH and CIH + ALI groups. CIH was applied for 6 h per day over 42 days, simulating an altitude of 3,000 m., approximately 14% O₂. Blood and lung samples w

SUBMITTER: Demirci Sahin A 

PROVIDER: S-EPMC12800019 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature