Increased plasma fibronectin mirrors intimal phenotypic switching of vascular smooth muscle cells in moyamoya arteriopathy.

ABSTRACT: Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive stenosis of large intracranial arteries and formation of fragile collateral vessels that can be triggered by a broad range of genetic and immune factors. Central to MMD pathology is excessive proliferation of vascular smooth muscle cells (VSMCs) in the intima of affected arteries associated with contractile-to-synthetic phenotypic switching, but the underlying molecular mechanisms remain unclear. To identify dysregulated pathways we studied a cohort of 12 patients with well-documented MMD, including one post-mortem autopsy case, using a multi-omics approach combining whole exome sequencing with plasma proteomics. In addition, we conducted an in-depth spatial proteomics analysis of an occluded artery retr

SUBMITTER: Asselman C 

PROVIDER: S-EPMC12800044 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature