Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein pre-formed fibrils Parkinson's disease mouse model.

ABSTRACT: Microglia response is proposed to be relevant in the neurogenerative process associated with alpha-synuclein (α-syn) pathology in Parkinson's disease (PD). STING is a protein related to the immune sensing of DNA and autophagy, and it has been proposed to be involved in PD neurodegeneration. To investigate this, we injected 10 µg of murine pre-formed fibrils (PFFs) of α-syn (or monomeric and PBS as controls) into the striatum of wild-type (WT) and STING^gt/gt mice, which lack functional STING. We examined motor behavior and brain pathology at 1- and 6-month post-injection. STING^gt/gt mice showed more motor changes associated with PFF injection than WT mice. STING^gt/gt mice had a differential immune response to PFF with early and sustained increased microglia

SUBMITTER: Klæstrup IH 

PROVIDER: S-EPMC12800057 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature