Identifying the biomarkers associated with G protein-coupled receptors of parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is a common neurological disorder. The research has found that G protein-coupled receptors (GPCRs) may affect the pathogenesis of PD. This study aimed to explore the value of GPCRs-related genes (GPCRs-RGs) with PD. In this study, the PD, control samples, and GPCRs-RGs were obtained from the public database. Then, the candidate genes were identified through differential expression genes obtained from differential expression analysis and GPCRs-RGs. Subsequently, biomarkers were obtained through machine learning, expression analysis, and ROC analysis. Notably, the nomogram, regulatory network, and gene set enrichment analysis (GSEA) of biomarkers were explored. In addition, a clustering analysis was adopted based on the biomarkers, and the immune infiltration were an

SUBMITTER: Yang H 

PROVIDER: S-EPMC12800089 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature