Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia.

ABSTRACT: Microglia are the resident immune cells of the central nervous system (CNS) and display diverse functions under both physiological and pathological conditions. The past decade has seen burgeoning interest in microglia function, with a variety of transgenic tools developed for specific genetic manipulation of microglia in various injury, disease, and developmental models. Although many of these models have been developed in mice, the ability to manipulate microglia in rats provides additional advantages to studying microglial function in the brain especially related to complex behavior. Using BAC transgenesis, our lab created a transgenic rat (Cx3cr1-CreERT2) that expresses a tamoxifen inducible Cre recombinase (CreERT2) under control of the microglial/macrophage specific fractalkine C-X3-C

SUBMITTER: Glotfelty EJ 

PROVIDER: S-EPMC12800110 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature