One health perspective of antibiotic resistance in enterobacterales from Southeast Asia: a systematic review and meta-analysis.

ABSTRACT: Antimicrobial resistance (AMR) in Enterobacterales poses serious public health, agricultural, and environmental threats. In Southeast Asia, a coordinated "One Health" approach is lacking, and fragmented evidence hampers targeted interventions. This study systematically quantify and analyse AMR prevalence across human, animal, and environmental sectors in Southeast Asia by conducting a meta-analysis of 137 observational studies from 2013 to 2023. We found that Ceftriaxone resistance in E. coli was highest in human samples (49.3%, 95% CI: 37.3-61.3; N = 2,640), followed by environmental (37.1%, 95% CI: 8.4-72.2; N = 288) and animal sources (11.2%, 95% CI: 1.6-27.9; N = 923). In humans, meropenem resistance was 13.0% in K. pneumoniae (95% CI: 2.0-31.3; N = 7,803) and 1.4% in E. coli (95% CI:

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12800116 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature