Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta.

ABSTRACT: Obesity concurrent with gestational diabetes mellitus (GDM) markedly increases the risk of adverse pregnancy outcomes, wherein placental dysfunction acts as a key mediating factor, however, the underlying mechanisms involved remain elusive. This pilot study was designed to focus on the role of mitochondria-endoplasmic reticulum contacts (MERCs) in obesity with GDM-induced placental dysfunction. Term placental tissues from pregnant women with obesity and GDM or healthy control were analyzed. Reduced cell count of placental trophoblasts, disorganized cell arrangement, and higher apoptosis rate were observed in placental tissue from women with obesity and GDM. In addition, oxidative stress levels and protein expression levels of endoplasmic reticulum (ER) stress markers phosphorylated inosito

SUBMITTER: Wang R 

PROVIDER: S-EPMC12800117 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature