Evaluate lymphovascular space invasion in endometrial cancer using diffusion-weighted imaging-based habitat imaging.

ABSTRACT: Lymphovascular space invasion (LVSI) is a key prognostic factor influencing treatment decisions in endometrial cancer (EC). Here, we evaluate whether diffusion-weighted imaging (DWI)-based habitat imaging can noninvasively identify LVSI in EC. We retrospectively analyzed 101 EC patients who underwent preoperative multi-b-value DWI examination between December 2020 and October 2024. EC lesions were decoded into four habitats determined by unsupervised K-means clustering using true diffusion coefficient (D), perfusion fraction (f), and mean kurtosis (MK) maps, and the volume fractions of each habitat were quantified. LVSI-positive EC ( n = 22 ) exhibited significantly higher volume fractions of Habitat 1 ( H1 ) and lower volume fractions of Habitat 2 ( H2 ) compared to LVSI-negative cases (

SUBMITTER: Wang W 

PROVIDER: S-EPMC12800121 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature