Hypergravity hinders proper dendritic patterning of a sensory neuron in the nematode Caenorhabditis elegans.

ABSTRACT: Altering gravity force can modify the three-dimensional spatial environment inside living animals that are adapted to earth's gravity. This may have deleterious effects on biological processes such as developmental patterning that requires proper molecular interactions in a 3D spatial environment. Here, we exposed the nematode Caenorhabditis elegans to a gravity force of 100G and observed effects to the development of the PVD touch sensory neurons that exhibit an intricate and stereotyped dendritic branch patterning. We found that hypergravity force increases the incidence of specific quaternary branching defects that occur in the narrow basement membrane space between muscle and epidermal layers during the L4 larval developmental stage. Normally the growing PVD neuron extends dendritic br

SUBMITTER: Moon JH 

PROVIDER: S-EPMC12800148 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature