Serum HDL subfractions are impaired by COVID-19 vaccine in patients with thymic epithelial tumors.

ABSTRACT: Patients with thymic epithelial tumors (TET), who have a high risk of developing immunological disorders such as immunodeficiency and autoimmunity, were included among frail patients eligible for the COVID-19 vaccinal program. We previously found an increase of serum biomarkers of inflammation in 25 of 44 (56,8%) TET patients after the second dose (T2) of mRNA vaccine (BNT162b2 from Pfizer-BioNTech), although none developed immune-related complications at this time point. In this study we have investigated the metabolic process of high-density lipoproteins (HDL) that are among the main players in inflammatory and immune modulation. To verify the impact of the vaccine on HDL metabolism in TET patients, we prospectively evaluated serum HDL and HDL subfractions at baseline and T2. Among the 4

SUBMITTER: Cernera G 

PROVIDER: S-EPMC12800207 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature