E2F transcription factors as multimodal biomarkers for pan-cancer management.

ABSTRACT: Early 2 factor (E2F) genes are transcription factors that interact with many DNAs and proteins. Studies have demonstrated that E2F genes can play an oncogenic role in different cancers, yet fewer have explored their effects on pan-cancers. In this study, E2F expression is systematically characterized in multiple types of cancer and its predictive value is determined. Several public databases (GEO, Cancer Genome Atlas (TCGA), cBioPortal, Kaplan-Meier Plotter and PrognoScan) were used to evaluate E2F genes differentially expressed between normal and tumor tissue in pan-cancer, we then investigated the correlation between expression levels of E2F and prognostic factors, clinicopathologic stage, gene mutation types, functional enrichment, drug sensitivity. This study also examined the relation

SUBMITTER: Yang S 

PROVIDER: S-EPMC12800231 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature