Randomized open-label non-inferiority trial of paracetamol or celecoxib for patients with chronic low back pain.

ABSTRACT: Pharmacological treatment is commonly used for patients with chronic low back pain (CLBP). However, very low-quality evidence exists for paracetamol as a treatment option for CLBP; therefore, recommendations are contradictory among the guidelines. This randomized controlled study aimed to compare the analgesic effects of paracetamol and celecoxib in a non-inferiority trial. This non-inferiority trial tested the hypothesis that paracetamol is as effective as celecoxib for the treatment of CLBP within a pre-specified non-inferiority margin. One hundred fifty-six patients with CLBP were considered eligible and randomly allocated to a group receiving paracetamol or celecoxib. The pain intensity was measured using a numerical rating scale as the primary outcome. Secondary outcomes were pain-rel

SUBMITTER: Hayashi K 

PROVIDER: S-EPMC12800242 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature