Proteomic profiling reveals age-related changes in transporter proteins in the human blood-brain barrier.

ABSTRACT: The Blood-Brain Barrier (BBB) is a selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. Its function continues to evolve postnatally, through aging, and disease states. Here we present a global proteomics analysis focused on the ontogeny and aging of proteins in human brain microvessels (BMVs), predominantly composed of brain endothelial cells. Our proteomic study quantified 6,223 proteins and revealed possible age-related alterations in BBB permeability due to basement membrane component changes through the early developmental stage and age-dependent changes in transporter expression. Age dependent expression changes were observed within nutrient transporters and transporters that play critical roles

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12800244 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature