Uncovering the metabolic impact of acute psychological stress in young adults.

ABSTRACT: Stress is associated with the onset of various neurological disorders, such as depression, post-traumatic stress disorder, and anxiety. Although extensively studied, the metabolic changes triggered in response to stress remain unclear. We conducted a descriptive observational study on acute stress responses in university students, combining psychometric, biochemical, and untargeted metabolomic analyses, along with machine learning predictions. In this study, forty participants underwent both relaxation and stress induction through a modified Trier Social Stress Test. Validated psychometric tests confirmed proper induction of both states. Although most biomarkers show significant changes under acute stress state, the machine learning predictive model identified salivary α-amylase and the St

SUBMITTER: Frempong GA 

PROVIDER: S-EPMC12800245 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature