Bone marrow-derived CD169⁺ macrophages promote autoimmune hepatitis by recruiting CCR2⁺ monocytes via secreting CCL12.

ABSTRACT: CD169⁺ macrophages, a unique subset of macrophages that cannot be simply defined as M1 or M2 macrophages, have been reported to be associated with various autoimmune diseases. However, the role of CD169⁺ macrophages in autoimmune hepatitis (AIH) is largely unknown. Here we found that the infiltration of CD169⁺ macrophages increased in the liver of patients with AIH and strongly positively correlated with inflammation degree. In a mouse model, depletion of CD169⁺ macrophages ameliorated ConA-induced acute liver injury. Immune homeostasis was also improved when CD169⁺ macrophages were depleted, as the infiltration of monocytes, macrophages and T cells decreased. Bone marrow-derived Ly6C^hiCD169⁺ macrophages were furt

SUBMITTER: Lin B 

PROVIDER: S-EPMC12800274 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature