Influence of endogenous estrogen exposure on the development of hypertension in a cohort study using multistate model analysis.

ABSTRACT: The protective effect of endogenous estrogen exposure (EEE) duration on hypertension (HTN) risk was shown previously. This study aimed to investigate the effect of EEE on the transitions of different blood pressure (BP) states using a multi-state Markov model. At the study initiation, 2911 normotensive women aged ≥ 20 years were eligible. The Multi-state Markov model, a robust statistical tool, was used to explore the transition probability of various HTN stages, including (I) normotensive to pre-HTN, (II) normotensive to HTN, and (III) pre-HTN to HTN. At the end of the follow-up of 2911normotensive women, 1544 (53%) and 78 (2%) developed pre-HTN and HTN, respectively. The protective effect of EEE duration was observed in all HTN transitions. The most protective effect was observed in tran

SUBMITTER: Mousavi M 

PROVIDER: S-EPMC12800285 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature