Modelling dysfunction-specific interventions for seizure termination in epilepsy.

ABSTRACT: Epileptic seizures result from abnormal synchronous neuronal firing caused by an imbalance between excitatory and inhibitory neurotransmission. While most seizures are self-limiting, those lasting over five minutes, termed status epilepticus, require medical intervention. Benzodiazepines, the first-line treatment, terminate seizures by enhancing GABAergic inhibition, but fail in approximately 36% of cases. In this paper, we employ a neural mass framework to investigate how different interventions influence brain dynamics and facilitate seizure termination. As seizures are characterized by persistent firing, we extend the classic Wilson-Cowan framework by introducing a term called sustenance which encodes factors that promote or discourage perpetual firing. The resulting model captures tran

SUBMITTER: Kamaraj AK 

PROVIDER: S-EPMC12800326 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature