KDASDB: A comprehensive and user-friendly database of alternative splicing dedicated to kidney diseases.

ABSTRACT: Kidney disease has long been a major public health concern, making it crucial to understand its causes, pathogenesis and progression for the development of effective prevention and treatment strategies. Alternative splicing (AS), an important post-transcriptional regulatory mechanism, has been increasingly recognized for its pivotal role in the pathogenesis and progression of kidney diseases. However, a dedicated database that systematically catalog AS events associated with kidney diseases is still lacking. In this study, we developed the Kidney Diseases Alternative Splicing Database (KDASDB, http://www.hxdsjzx.cn/KDASDB), which integrates 90,273 alternative splicing events (ASEs) derived from 2406 samples, encompassing 29 distinct kidney diseases and 126 projects across human and mouse.

SUBMITTER: Kuang Y 

PROVIDER: S-EPMC12800380 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature