Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis: Prevalence, Incidence, Clinical Predictors, and Effect of Tafamidis.

ABSTRACT:

Background

Atrial fibrillation/flutter (AF) is common in transthyretin cardiac amyloidosis (ATTR-CA). The CHARGE-AF score has not been validated in ATTR-CA. The Columbia staging system is prognostic for survival, but its utility in predicting incident AF is unknown.

Objectives

The authors aim to determine the predictors of prevalence and incidence of AF and the effect of tafamidis.

Methods

This is a retrospective cohort study of 419 patients with ATTR-CA. AF was ascertained from review of electrocardiograms, extended rhythm, device interrogations, and charted history. Binary logistic regression assessed for factors associated with prevalent AF. Cox regression time-to-event analysis assessed for factors associated with incident AF.

Results

AF was present in 58%

SUBMITTER: Chan N 

PROVIDER: S-EPMC12800393 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature