Proton pump inhibitors are associated with increased risk of pseudoarthrosis after lumbar fusion.

ABSTRACT:

Background

Pseudoarthrosis is a major complication following lumbar spine fusion, leading to revision surgery, increased disability, and substantial economic burden. Proton pump inhibitors (PPIs) are commonly used in the perioperative period, but their impact on fusion success remains poorly defined.

Methods

This retrospective cohort study utilized the TriNetX research database to identify adult patients undergoing lumbar spine fusion. Patients were divided into 2 cohorts based on documented PPI use within 30 days postoperatively and underwent 1:1 propensity score matching based on demographic and clinical characteristics. The incidence of pseudoarthrosis was assessed using diagnostic coding, and risk was compared using risk ratios and Kaplan-Meier survival analysis. An age-

SUBMITTER: Romoff M 

PROVIDER: S-EPMC12800474 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature