The effect of PEGylation on surface tethering of liposomes via DNA nanotechnology.

ABSTRACT: Polyethylene glycol (PEG) is widely used in liposome formulation due to its blocking properties and ability to prolong circulation in vivo to create biomimetic liposomes and drug delivery devices. Similarly, membrane-embedded DNA nanotechnology is increasingly used to modulate cellular behaviour and communication. However, there is a gap in knowledge in how PEG-lipid formulations can be optimized for both liposome properties and control of selective DNA hybridization. To address this, we systematically investigated the effect of liposome PEG content on DNA mediated tethering of liposomes to glass surfaces. We formulated liposomes of two different lipid compositions (DOPE/DOPC or DPhPC), with varying amounts of PEGylated lipid (0%-50%). We measured the effect of increased PEG content on lip

SUBMITTER: Gaston JP 

PROVIDER: S-EPMC12800489 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature