Liver transplantation for hepatopulmonary syndrome: A systematic review and meta-analysis.

ABSTRACT:

Background & aims

Hepatopulmonary syndrome (HPS) is a severe pulmonary vascular complication of liver disease. Liver transplantation (LT) is the only definitive treatment, yet a contemporary synthesis of LT outcomes in HPS, alongside persisting uncertainties, is lacking.

Methods

We conducted a systematic review and meta-analysis of 22 studies to evaluate HPS prevalence, post-LT survival, and HPS resolution.

Results

Pooled HPS prevalence was 17.2% (11.6-24.7%, n = 1,171 studied patients) among patients with cirrhosis evaluated for LT, 26.1% (18.5-35.5%, n = 629) in patients with portal hypertension evaluated for LT and 21.6% (11.2-37.4%, n = 737) in LT recipients. Under current model for end-stage liver disease (MELD) exception policies, waitlist mortality was 13.1% (0

SUBMITTER: Verstraeten M 

PROVIDER: S-EPMC12800508 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature