Interaction Between Maternal Obesity and Metabolic Dysfunction in Gestational Hypertension and Preeclampsia: A Prospective Birth Cohort Study.

ABSTRACT: This prospective birth cohort study, conducted in China with 21 893 singleton pregnant women, aimed to investigate the association between metabolic obesity phenotypes and the risks of gestational hypertension (GH) and preeclampsia (PE), as well as to explore the potential interaction between obesity and metabolic abnormalities in relation to these conditions. Participants were categorized according to their pre-pregnancy BMI and metabolic status into different obesity metabolic phenotypes. The diagnosis of GH and PE was based on blood pressure measurements, evidence of end-organ dysfunction, or proteinuria occurring after 20 weeks of gestation. The results indicated that, compared to metabolically healthy normal-weight women, those with metabolically unhealthy normal weight, metabolically

SUBMITTER: Chen J 

PROVIDER: S-EPMC12800569 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature