Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models.

ABSTRACT:

Objectives

Tuberculosis (TB) remains a global health challenge, with current antibiotic therapies being limited by long treatments, side effects and multidrug-resistant mycobacterial strains. In addition, Mycobacterium tuberculosis (Mtb), the main causative agent of TB, employs evasion mechanisms particularly within alveolar macrophages being the primary host cells. Conventional therapies fail to modulate macrophage function or effectively target host immunity, which is crucial in TB pathogenesis. Emerging evidence points to induced pluripotent stem cell-derived macrophages (iMacs) with enhanced bactericidal activity as a promising cell-based approach for TB treatment. Therefore, this study aimed to compare iMacs with blood monocyte-derived macrophages (MDMs) in respo

SUBMITTER: Paasch D 

PROVIDER: S-EPMC12800570 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature