Molecular Landscape and Predictive Significance of Programmed Cell Death-Related Genes in Sepsis.

ABSTRACT: Sepsis, a systemic inflammatory response to infection, remains a significant health challenge with high morbidity and mortality rates. The molecular mechanisms underlying sepsis, particularly the role of programmed cell death (PCD), are not fully understood. This study is aimed at elucidating the transcriptomic changes associated with sepsis, emphasizing PCD, and identifying potential diagnostic biomarkers. Transcriptome data from sepsis and control samples were extracted from the GEO website. Differential expression analysis identified genes perturbed in sepsis. WGCNA revealed 14 highly connected modules, with the turquoise module showing the strongest association with sepsis. A set of 262 hub genes was identified, which were mainly associated with apoptotic signaling pathways. Seven prog

SUBMITTER: Min S 

PROVIDER: S-EPMC12800578 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature