Urinary Podocyte Loss is Associated With Treatment Response in Patients With Primary Nephrotic Syndrome.

ABSTRACT:

Introduction

The disease course of primary nephrotic syndrome (PNS) is highly variable, and is difficult to predict at onset. PNS is characterized by podocyte injury and loss. We hypothesized that measurement of urinary podocyte loss is associated with treatment response in patients with PNS.

Methods

We included 21 controls, and 59 patients with PNS (minimal change disease [MCD], n =8; focal segmental glomerulosclerosis [FSGS], n = 9; membranous nephropathy [MN]. n = 42). MCD and FSGS were considered manifestations of the same disease entity, and analyzed as one group. Patients' baseline clinical and follow-up data were recorded. Urinary sediments were collected and stained for podocyte-specific markers, and analyzed using fluorescence-activated cell sor

SUBMITTER: van den Berge BT 

PROVIDER: S-EPMC12800585 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature