Renal Response Status and Long-Term Kidney Outcomes in Childhood-Onset Lupus Nephritis.

ABSTRACT:

Introduction

The aim of this study was to evaluate the relationship between modified primary efficacy renal response (PERR, mPERR) and modified complete renal response (CRR, mCRR) at 24 months postbiopsy and long-term kidney outcomes in childhood-onset lupus nephritis (LN, cLN).

Methods

We conducted a cohort study of biopsy-proven cLN diagnosed at the age of <18 years between 2001 and 2023, with prospective data collected from 2021 to 2025. We examined the relationship between modified versions of PERR (mPERR) and CRR (mCRR) at 24 months postbiopsy and survival free from advanced chronic kidney disease (CKD), including kidney failure (CKD 4-5D/T).

Results

One hundred seven Chinese children (93 female; median age at diagnosis: 13.7, interquartile range [IQR]: 11.0-16.6

SUBMITTER: Chan EY 

PROVIDER: S-EPMC12800599 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature