Frog-Derived Peptide RL-RF10 Facilitates Gingival Repair and Regeneration Through the Integrin αvβ3/p38/Snail1 Axis.

ABSTRACT:

Background

Despite advancements in dental therapies, insufficient gingival tissue remains a significant challenge. Currently, no specific medications promote the regeneration of gingival tissue, with existing treatments primarily redistributing tissue rather than restoring it. Amphibian bioactive peptides show promise but remain underexplored in gingival repair. This study investigates the potential of RL-RF10, a peptide derived from frogs, for gingival tissue repair.

Methods

The localization of RL-RF10 was monitored using fluorescein isothiocyanate labelling. The effects of RL-RF10 on the biological characteristics of human oral keratinocytes were investigated through live/dead staining, cell counting kit-8 assays, cell cycle analysis, and wound healing assays. Additionally

SUBMITTER: Cheng T 

PROVIDER: S-EPMC12800600 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature