Establishing Epidemiological Cutoff Values for <i>Helicobacter pylori</i> Strains in Korea: A Model-Based Analysis of Antibiotic Resistance Patterns.

ABSTRACT:

Background/aims

The absence of standardized clinical minimum inhibitory concentration (MIC) breakpoints for Helicobacter pylori infection has resulted in inconsistent resistance definitions, even within the same research group in Korea. Therefore, establishing epidemiological cutoff values (ECOFFs) is essential for standardization.

Methods

The MIC distributions for antibiotics commonly used against H. pylori infection in South Korea were analyzed from 2015 to 2023. A total of 5,925 primary H. pylori isolates were collected from five data sources, and MIC values were determined using the serial 2-fold agar dilution method. The ECOFFinder program was used to establish ECOFFs for six antibiotics.

Results

The tentative ECOFFs for amoxicillin and clari

SUBMITTER: Noh JH 

PROVIDER: S-EPMC12800676 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature