Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects.

ABSTRACT: Infected bone defects (e.g., osteomyelitis) present a complex clinical challenge characterized by persistent biofilms, intracellular pathogens, and compromised bone regeneration. We hypothesized that a bioadaptive magnesium implant with sequential coating/substrate degradation could render staged anti-infective and pro-regenerative therapy. To this end, we engineered TNE@AHA_C implants consisting of a Mg-Zn alloy substrate functionalized with a multilayered coating: a corrosion-resistant MgF₂ underlayer, a polydopamine/polyethyleneimine adhesive interlayer, and an infection-responsive aldehyde-modified hyaluronic acid (AHA) hydrogel toplayer embedded with microbe-targeting Fe₃O₄ nanozymes (TNE). The implants demonstrated improved hydrophilicity an

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12800689 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature