The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer.

ABSTRACT: Platinum-based chemotherapy remains the cornerstone of the treatment of epithelial ovarian cancer (EOC); however, platinum resistance is a major cause of tumor recurrence and mortality in EOC patients. This study reports the mechanism by which EOC cells develop resistance to cisplatin by inhibiting the ferroptosis. Immunohistochemical analysis of human EOC tissues revealed that low p27 expression significantly correlated with poor response to chemotherapy and unfavorable patient prognosis. Functionally, CRISPR/Cas9-mediated p27 KO increased cisplatin resistance in EOC cells in both in vitro and in vivo models. RNA sequencing and functional assays demonstrated that p27 enhanced cisplatin sensitivity by facilitating drug-induced ferroptosis in EOC cells. Mechanistically, luciferase reporter

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12800695 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature