Real-world evaluation of interstitial lung disease/pneumonitis in patients treated with trastuzumab deruxtecan for HER2-positive advanced or recurrent gastric cancer: a postmarketing surveillance study in Japan.

ABSTRACT:

Background

Interstitial lung disease (ILD)/pneumonitis is an important identified risk associated with trastuzumab deruxtecan (T-DXd) treatment, but there are few reports of T-DXd-related ILD in a real-world setting.

Materials and methods

This observational, multicenter, all-patient postmarketing surveillance study in patients with gastric cancer treated with T-DXd in a real-world setting in Japan investigated the incidence and characteristics of drug-related ILD and factors of interest associated with its incidence. All patients who initiated T-DXd treatment for human epidermal growth factor receptor 2 (HER2)-positive unresectable advanced or recurrent gastric cancer between September 2020 and December 2021 were enrolled and observed until T-DXd therapy termination or compl

SUBMITTER: Kawakami H 

PROVIDER: S-EPMC12800766 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature