Systemic immunomodulating therapies for epidermal necrolysis (Stevens-Johnson syndrome/toxic epidermal necrolysis): A systematic review and meta-analysis.

ABSTRACT:

Background and objectives

Epidermal necrolysis is a rare but severe cutaneous reaction with high mortality. Limited evidence exists regarding the efficacy of systemic immunomodulatory therapies (SITs). Our systematic review aimed to compare SITs with supportive care or one another.

Patients and methods

Randomized controlled trials and controlled observational studies (≥ 5 patients of all ages per arm) using the international consensus classification for EN (Bastuji-Garin, 1993) with no significant baseline differences were included. We searched MEDLINE, Embase, and Cochrane CENTRAL (January 1, 1993-January 22, 2024). Two reviewers independently extracted study and outcome data. A random-effects meta-analysis was performed.

Results

The main outcome was mortality. Secon

SUBMITTER: Heuer R 

PROVIDER: S-EPMC12800890 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature