Adjuvant Chemotherapy in Breast Cancer after Neoadjuvant Therapy: Essential or Optional?

ABSTRACT:

Purpose

This study aimed to evaluate the impact of postoperative adjuvant chemotherapy (AC) on survival outcomes in breast cancer (BC) patients who have already undergone neoadjuvant chemotherapy (NAC) followed by surgery.

Materials and methods

Data from a population-based cohort (2010-2020) were analyzed for BC patients treated with NAC and surgery. Univariate and multivariate Cox regression identified prognostic factors for overall survival (OS), and a nomogram was developed and validated. Personalized scores from the nomogram were used for risk stratification to assess the effect of postoperative AC.

Results

A total of 15,921 BC patients were analyzed, with 11,144 in the training cohort and 4,777 in the validation cohort. The key prognostic indicators for OS includ

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12800950 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature