Association of Physical Activity with Dementia Risk in Cancer Survivors: A Korean Nationwide Cohort Study.

ABSTRACT:

Purpose

This study aimed to investigate the impact of physical activity on dementia risk among cancer survivors in South Korea.

Materials and methods

This retrospective, population-based cohort study included 344,152 cancer survivors identified from the National Health Insurance Service database in South Korea. The mean follow-up time was 5.81 years. Different levels of physical activity post-cancer diagnosis, ranging from inactive to highly active, were assessed. The primary outcome was the incidence of overall dementia, Alzheimer's disease, and vascular dementia. Secondary outcomes included dementia risk stratified by cancer type and treatment (chemotherapy and radiation).

Results

Of the total participants, 24,363 (7.08%) developed dementia. The risk of overall deme

SUBMITTER: Lee SK 

PROVIDER: S-EPMC12800954 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature