Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal Cancers.

ABSTRACT:

Purpose

Molecular characteristics of synchronous colorectal cancers (SCRCs) remain incompletely elucidated, despite their importance in targeted therapy selection. We compared the molecular characteristics and somatic mutations between SCRCs.

Materials and methods

This retrospective study (2012-2014) included 98 consecutive patients with surgically resected SCRCs. Molecular characteristics, including microsatellite instability (MSI) and tumor-infiltrating lymphocytes (TILs), were analyzed for all cancer lesions. The intertumoral heterogeneity of SCRCs was evaluated using whole-exome sequencing (WES) for 18 cancers from nine patients with at least one MSI-high (MSI-H) tumor.

Results

Twelve patients had at least one MSI-H tumor; five showed discordant MSI status. Mucino

SUBMITTER: Lee HG 

PROVIDER: S-EPMC12800958 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature