<i>Mycobacterium tuberculosis</i> transmission dynamics within prisons: a population-based genomic study.

ABSTRACT:

Background

One barrier to intervening in the global tuberculosis pandemic is that it is unknown whether Mycobacterium tuberculosis transmission largely occurs through repeated close exposures among few contacts or many shorter-term contacts. Identifying sources of transmission is particularly urgent in congregate settings like prisons with high incidence of infection. Our aim was to identify the type of contacts associated with M. tuberculosis transmission risk within prisons.

Methods

We conducted genomic surveillance in a prison system in Central West Brazil. We whole genome sequenced M. tuberculosis isolates and collected detailed incarceration histories. We modeled transmission linkages as a function of different types of prison exposures, using genom

SUBMITTER: Walter KS 

PROVIDER: S-EPMC12800999 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature