Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson's disease.

ABSTRACT:

Introduction

Tremor is a prevalent and disabling motor symptom in Parkinson's disease (PD). The role of the serotonergic system in Parkinsonian tremor remains unclear. We aimed to investigate whether functional connectivity (FC) of the dorsal (DRN) and median (MRN) raphe nuclei is associated with tremor in PD.

Methods

Forty PD patients with tremor dominant (TD-PD), 42 PD patients with postural instability and gait disturbance dominant (PIGD-PD), and 40 healthy controls (HCs) were enrolled. Resting-state functional MRI was used to investigate altered FC of the DRN and MRN in TD-PD patients compared to HCs and PIGD-PD patients. Subsequently, correlations between FC of the raphe nuclei and motor-related clinical variables were analyzed.

Results

Both TD-PD and PIGD-PD pat

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC12801054 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature