Prevalence of Central Sensitization in Postural Tachycardia Syndrome.

ABSTRACT:

Importance

A previous study showed a high prevalence of central sensitization syndrome (CSS) in patients with autonomic symptoms. The prevalence of CSS in postural tachycardia syndrome (POTS), a form of dysautonomia, is unknown.

Objectives

To analyze the prevalence of CSS in POTS.

Design, setting, and participants

This case-control study included patients with a POTS diagnosis confirmed by autonomic testing at Brigham and Women's Faulkner Hospital between 2022 and 2025. Data were analyzed from April to August 2025.

Exposure

POTS with and without CSS.

Main outcomes and measures

Central Sensitization Inventory (to assess central sensitization syndrome [CSS]), COMPASS-31 (autonomic symptoms), Neuropathy Total Symptom Score-6 (NTSS-6, sensory symptoms), PROM

SUBMITTER: Mathew GT 

PROVIDER: S-EPMC12801080 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature